![]() ![]() Excessive loss of muscle mass is a poor prognostic indicator, resulting in longer hospitalization and recovery time, impairing the efficacy of many different therapeutic treatments, as well as health increasing care cost and decreasing patient's quality of life. Side effects of reduced physical activity can lead to paralysis, joint stiffness and pain, with protective limitations of motion and mental disorders and main metabolic alterations such as insulin resistance, thromboembolic disease, disuse osteoporosis, respiratory and musculoskeletal complications. From a clinical point of view, complications arising from immobilization or physical inactivity might worsen primary disease or trauma and might become the most relevant problem to treat rather than the primary disorder. During prolonged bed rest (due to aging, recovery from injuries, sepsis or other pathological conditions) skeletal muscle undergoes severe loss which results in decreased physical performance. Even though the practice is still commonly used for an array of conditions, randomized clinical trials failed to show bed rest as an effective treatment for any illness. Moreover, ZDF-Cage rats did not lose muscle mass and force but performed a reduced total physical activity level (-22%).Ĭonclusions The present study results suggests that 28 days of immobilization (in a space-restriction model) significantly impaired glucose tolerance with concomitant reduced plasmatic adiponectin levels and GLUT4 expression in soleus muscle of type 2 diabetic rats.Īlthough bed rest was a common therapeutic intervention in chronically ill patients providing beneficial effects by procuring patient comfort and contributing to recovery, in the past 50 years it has become apparent that the effects of bed rest may be harmful. Although no apparent changes were observed either in fasting plasma glucose or insulin levels, a trend towards an increase in the HOMA-IR index and decreased levels of plasma adiponectin (-30%) were observed in ZDF-Cage animals. GLUT4 gene expression in red soleus muscle of ZDF-Cage animals was reduced 2.5-fold in comparison with ZDF-Con rats. The Area Under the Curve (AUC) values for plasma glucose concentration in ZDF-Cage rats were significantly increased (approximately 4-fold as compared with ZDF-Con rats). Methods and results 13wk old male Zucker diabetic fatty (ZDF) rats were randomly divided into two groups: control (ZDF-Con) and cage-immobilized animals (ZDF-Cage) for 28 consecutive days in a space-restricted cage. ![]() The aim of the present study was to investigate the impact of bed rest on the metabolic changes in type 2 diabetes mellitus, with particular interest in skeletal muscle mass and function and metabolism. Patients with diabetes are hospitalized frequently (3-fold greater) and with longer admissions (30% longer) than the non-diabetic subjects. This metabolic disorder is characterized by insulin resistance, β-cell dysfunction and elevated hepatic glucose output. Aims Type 2 Diabetes Mellitus affects more than 350 million people worldwide. ![]()
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